The Zahler Lab at UCSC
pre-mRNA splicing and micro RNA function in mammals and worms

The Mammals

• Alan M. Zahler, Ph.D. - email
• Jennifer Kabat, Ph.D. - email
• Sergio Barberan, Ph.D. - email
• Mary Ann Dassah - email
• Nicole Lambert - email
• James Williams - email
• Marissa Perez - email
• Pedro Medina - email

  Recent Lab Alumni

• Sam Guoping Gu, Ph.D. - email
• Jim Kent, Ph.D. - email
• Massimo Caputi, Ph.D. Associate Professor - email
• Hiram Clawson - email
• Valerie Hunt - email
• Mustapha Ali - email
• Chandra Kilburn - email
• Oliver Fregoso - email
• Armando Villalta - email

The Worms

C. elegans expressing green fluorescent protein alternative splicing reporter constructs

The Intronerator

The Intronerator is a tool for browsing cDNA alignments in the context of the C. elegans genome. The Intronerator includes a catalog of alternatively spliced genes, an intron database, and many other useful tools for doing molecular biology in the worm. In addition, an alignment of the entire genomes of C. briggsae and C. elegans can be viewed. UPDATED JUNE 2003 to incorporate the complete C. elegans genome sequence and over 100,000 new ESTs and cDNAs. The UCSC Genome Browser contains more advanced functions for looking at up-to-date C. elegans genome annotation, BLAT alignments, and worm comparative genetics.

Useful Links

• Cancer Cell Biology - Bio114
• UCSC Genome Browser - Our internationally-recognized homegrown browser for Human, Chimp, Mouse, Rat, Fugu, C. elegans, C. briggsae, C. remanei, etc., etc. genomes
• PubMed - when you need to find a scientific abstract fast
• UCSC Science Library's On-line Journal Access from Off-Campus
• BLAST Searching at NCBI - (be warned, one homolog is never enough).
• Pfam Protein Family Database of Alignments
• Splice Site Prediction By Neural Net
• Caenorhabditis elegans WWW Server
• Wormbase C. elegans Database
• C. elegans Single Nucleotide Polymorphism Database
• Institute for Scientific Information - Web of Science
• UCSC MCD Graduate Program - high quality molecular bio in the redwoods.

How to Reach Us

Zahler Lab
Department of Molecular, Cellular and Developmental Biology
and Center for Molecular Biology of RNA
Sinsheimer Labs
University of California, Santa Cruz
Santa Cruz, CA 95064
(831) 459-5127

Professor Zahler's Office

(831) 459-5131

Background image is an electron micrograph of the tandemly linked s36 and s38 chorion genes of Drosophila melanogaster showing RNP assembly on nascent transcripts; image courtesy of Yvonne Osheim, Oscar Miller Jr. and Ann L. Beyer