| The Vrielink laboratory uses
crystallographic methods to investigate enzyme function and mechanism.
Our endeavors can be subdivided into two major categories: redox catalysis
in flavoproteins and substrate channeling in multifunctional enzymes.
For the former, we are studying the structural and electronic features
of flavoenzymes to understand how flavin chemistry is modulated to
achieve specificity of function. For the latter, we are interested
in determining the macromolecular mechanisms that regulate efficient
substrate channeling between different active sites of the enzyme while
sequestering the substrate away from bulk phase. Our work reveals important
insights into catalytic mechanisms, pushing the boundaries of current
crystallographic methodology. |
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