Sullivan Laboratory
The Sullivan Laboratory
Molecular, Cell, and Developmental Biology
University of California, Santa Cruz

Table 1: Mutations that Specifically Disrupt the Cortical Divisions of Drosophila

Gene/ Map
Protein
Localization
interphase/prophase
Furrow
Phenotype
Possible Primary Defect
Centrosome
        
nuf/ 70D2
 coiled-coil
 cytoplasm/centrosome
Incomplete 
Recruitment failure of dah/actin/vesicles 
sced/ 43A
 no homology
 Centrosome/furrow
 Absent
 Failure to organize actin at furrows
cnn/ 50A
 leucine-zipper
 Centrosome/centrosome
 Absent
 No astral MTs, actin cap/furrow failure
Cortical
        
dah/ 13C1
 Dystropin
 Vesicles/furrow
 No invagination
 Vesicles fail to incorporate into furrows
dia/ 38E4-6
 Formin
 Furrow/furrow
 No Invagination
 Anillin and Septin do not locate to furrow
scra/ 43E1-3
 Anillin
 Furrow/furrow
 ?
 
Cell Cycle
 
 
 
  
grp/ 36A6-7
Chk1 kinase
 Nucleus/cytoplasm
 Partial Invagination
Failure of myosin furrow recruitment 
mei41/14C3-4
 ATM kinase
 ?
 ?
 
dwee/ 27C3-4
 Wee kinase
?
 ?
 
Metabolic
 
 
 
 
sun/ 13F3-5
 ATP  synthase
 ?
 Incomplete
 
gs(1)/ 21B1
 Glutamine synthase
 ?
 ?
 
Not Cloned
 
 
 
 
spg/ 98E-99A
 ?
 ?
 Absent
Failure to organize actin caps and furrows 
dal/ 31F-32D
 ?
 ?
 Incomplete
 Centrosome separate and positioning
wad/ 20D
 ?
 ?
 No invagination
 Vesicles fail to incorporate into furrows

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Last updated: October 26, 2001